How does Tirzepatide work?

Understanding How Tirzepatide Works for Weight Loss

Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, making it unique in its class. Here’s how it promotes weight loss:

1. Dual Hormone Action: Tirzepatide combines the effects of GIP and GLP-1, both of which play significant roles in regulating appetite and glucose metabolism. By activating these receptors, tirzepatide enhances insulin secretion, reduces glucagon levels, and slows gastric emptying, leading to improved glycemic control and reduced appetite.
2. Appetite Regulation: By targeting both GIP and GLP-1 receptors, tirzepatide effectively suppresses appetite and enhances feelings of fullness. This dual action is more potent than targeting GLP-1 alone, contributing to greater weight loss.
3. Clinical Efficacy: Clinical trials have shown that tirzepatide results in significant weight loss in individuals with obesity. In a phase 3 trial, participants using tirzepatide experienced substantial reductions in body weight compared to those on a placebo.

For more detailed information, refer to the original clinical studies available on PubMed.